pentobarbital raises toxicity of buprenorphine, extensive-acting injection by pharmacodynamic synergism. Modify Therapy/Monitor Intently. Coadministration of buprenorphine and benzodiazepines or other CNS depressants improves threat of adverse reactions which includes overdose, respiratory depression, and death. Cessation of benzodiazepines or other CNS depressants is chosen generally.
pentobarbital will lower the level or outcome of diltiazem by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
pentobarbital will lower the level or impact of prednisone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
This drug may perhaps increase the metabolism of estradiol when administered concurrently; patients on oral contraceptives are becoming Expecting when concurrently addressed with antiepileptic drugs; propose an alternate contraceptive technique to Ladies having this drug
pentobarbital will decrease the extent or result of bedaquiline by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Stay clear of coadministration of bedaquiline with potent CYP3A4 inducers as a consequence of possible for reduced therapeutic impact
pentobarbital will lower the extent or effect of irinotecan liposomal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
Both increases toxicity of the other by pharmacodynamic synergism. Steer clear of or website Use Alternate Drug. Profound sedation, respiratory despair, coma, and Demise may possibly outcome if coadministered. Reserve concomitant prescribing of such drugs in people for whom other procedure possibilities are inadequate. Limit dosages and durations on the minimum essential. Monitor closely for signs of respiratory despair and sedation.
pentobarbital will decrease the extent or outcome of montelukast by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Not known.
pentobarbital will reduce the extent or influence of zolpidem by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unfamiliar.
pentobarbital will decrease the level or result of siponimod by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of siponimod with a drug that causes reasonable CYP2C9 plus a average or solid CYP3A4 inducer just isn't advised.
Drugs that have amount boundaries linked with Every prescription. This restriction normally restrictions the amount from the drug that can be covered.
Use an alternate technique of contraception or a backup method when enzyme inducers are utilized with merged hormonal contraceptives (CHCs), and go on backup contraception for 28 times immediately after discontinuing enzyme inducer to guarantee contraceptive trustworthiness.
pentobarbital will decrease the extent or influence of propafenone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
pentobarbital will lower the level or influence of isavuconazonium sulfate by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.